Publications


h-index:  30 (28 excluding self-citations)

Researchgate "RG score":  40.3 (top 2.5 percentile rank)

Public-domain articles are available through Researchgate (click here) as well as PubMed. ​

If you are unable to access any of our papers, please email us to request a reprint or preprint.
Articles with a PMC ID are available from PubMed (click anywhere)

Ayyadevara S, Balasubramaniam M, Suri P, Mackintosh SG, Tackett AJ, Sullivan DH, Shmookler Reis RJ, Dennis RA.  Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans. Aging (Albany NY). 2017  doi: 10.18632/aging.101141. [Epub ahead of print]

Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R,
Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ. Proteins that
mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus
from normal controls. Aging cell 2016; 15:924-939. PMID: 27448508, PMCID: PMC5013017

Ayyadevara S, Balasubramaniam M, Johnson J, Alla R, Mackintosh SG, Shmookler Reis
RJ. PIP3-binding proteins promote age-dependent protein aggregation and limit
survival in C. elegans. Oncotarget 2016; 7:48870-86.   PMID: 27429199

Ayyadevara S, Mercanti F, Wang X, Mackintosh SG, Tackett AJ, Prayaga SV, Romeo F,
Shmookler Reis RJ, Mehta JL. Age- and Hypertension-Associated Protein Aggregates
in Mouse Heart Have Similar Proteomic Profiles. Hypertension  2016; 67:1006-1013.
NIHMSID: NIHMS758723  PMID: 26975704, PMCID: PMC4833546

Alagpulinsa DA, Ayyadevara S, Yaccoby S, Shmookler Reis RJ. A Cyclin-Dependent
Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes
Multiple Myeloma Cells to PARP Inhibition. Molecular cancer therapeutics 2016;
15:241-250. NIHMSID: NIHMS741414  PMID: 26719576, PMCID:
PMC4747838

Kogan V, Molodtsov I, Menshikov LI, Shmookler Reis RJ, Fedichev P. Stability
analysis of a model gene network links aging, stress resistance, and negligible
senescence. Scientific reports 2015; 5:13589. PMID: 26316217,
PMCID: PMC4551969

Ding Z, Liu S, Wang X, Deng X, Fan Y, Shahanawaz J, Shmookler Reis RJ, Varughese
KI, Sawamura T, Mehta JL. Cross-talk between LOX-1 and PCSK9 in vascular tissues.
Cardiovascular research 2015; 107(4):556-67.  PMID: 26092101

Alagpulinsa DA, Yaccoby S, Ayyadevara S, Shmookler Reis RJ. A peptide nucleic
acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan
treatment. Cancer biology & therapy 2015; 16(6):976-86. PMID: 25996477,
 PMCID: PMC4622566  

Ayyadevara S, Balasubramaniam M, Gao Y, Yu LR, Alla R, Shmookler Reis R. Proteins
in aggregates functionally impact multiple neurodegenerative disease models by
forming proteasome-blocking complexes. Aging cell 2015; 14:35-48. PMID: 25510159
PMCID: PMC4326912

Alagpulinsa DA, Ayyadevara S, Shmookler Reis RJ. A Small-Molecule Inhibitor of
RAD51 Reduces Homologous Recombination and Sensitizes Multiple Myeloma Cells to
Doxorubicin. Frontiers oncology 2014; 4:289.  PMID: 25401086, PMCID: PMC4214226

Ayyadevara S, Tazearslan C, Alla R, Jiang JC, Jazwinski SM, Shmookler Reis RJ.
Rec-8 dimorphism affects longevity, stress resistance and X-chromosome
nondisjunction in C. elegans, and replicative lifespan in S. cerevisiae.
Frontiers genetics 2014; 5:211. PMID: 25136348, PMCID: PMC4120681

Foster SR, Galanzha EI, Totten DC, Beneš H, Shmookler Reis RJ, Zharov VP.
Photoacoustically-guided photothermal killing of mosquitoes targeted by
nanoparticles. J biophotonics. 2014; 7:465-473. PMID: 23450780

Bharill P, Ayyadevara S, Alla R, Shmookler Reis RJ. Extreme Depletion of PIP3
Accompanies the Increased Life Span and Stress Tolerance of PI3K-null C. elegans
Mutants. Frontiers genetics. 2013; 4:34. PMID: 23543623, PMCID: PMC3610087

Ayyadevara S, Bharill P, Dandapat A, Hu C, Khaidakov M, Mitra S, Shmookler Reis
RJ, Mehta JL. Aspirin inhibits oxidant stress, reduces age-associated functional
declines, and extends lifespan of Caenorhabditis elegans. Antioxidant redox
signaling 2013; 18:481-490.  PMID: 22866967

Shmookler Reis RJ. Coming to terms with complexity: limits to a reductionist view
of aging. Frontiers genetics 2012; 3:149.  PMID: 22969788, PMCID: PMC3427912

Wuttke D, Connor R, Vora C, Craig T, Li Y, Wood S, Vasieva O, Shmookler Reis R,
Tang F, de Magalhães JP. Dissecting the gene network of dietary restriction to
identify evolutionarily conserved pathways and new functional genes. PLoS
Genetics. 2012; 8(8):e1002834.  PMID: 22912585, PMCID: PMC3415404

Rose MR, Flatt T, Graves JL, Greer LF, Martinez DE, Matos M, Mueller LD,
Shmookler Reis RJ, Shahrestani P. What is Aging? Frontiers genetics. 2012;
3:134. PMID: 22833755, PMCID: PMC3400891

Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H,
Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev
V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A,
Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M,
Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P. The second
international conference "genetics of aging and longevity". Aging. 2012;
4(5):305-17. PubMed [journal] PMID: 22661237

Nedosekin DA, Galanzha EI, Ayyadevara S, Shmookler Reis RJ, Zharov VP.
Photothermal confocal spectromicroscopy of multiple cellular chromophores and
fluorophores. Biophysical journal. 2012; 102(3):672-81. PubMed [journal] PMID:
22325291, PMCID: PMC3274827

Shmookler Reis RJ, Ayyadevara S, Crow WA, Lee T, Delongchamp RR. Gene categories
differentially expressed in C. elegans age-1 mutants of extraordinary longevity:
new insights from novel data-mining procedures. The journals of gerontology.
Series A, Biological sciences and medical sciences. 2012; 67:366-75. PubMed
[journal] PMID: 22021389

Vertino A, Ayyadevara S, Thaden JJ, Shmookler Reis RJ. A narrow quantitative
trait locus in C. elegans coordinately affects longevity, thermotolerance, and
resistance to paraquat. Frontiers in genetics. 2011; 2:63. PubMed [journal] PMID:
22303358, PMCID: PMC3268616

Pal J, Bertheau R, Buon L, Qazi A, Batchu RB, Bandyopadhyay S, Ali-Fehmi R, Beer
DG, Weaver DW, Shmookler Reis RJ, Goyal RK, Huang Q, Munshi NC, Shammas MA.
Genomic evolution in Barrett's adenocarcinoma cells: critical roles of elevated
hsRAD51, homologous recombination and Alu sequences in the genome. Oncogene.
2011; 30(33):3585-98. NIHMSID: NIHMS274385 PubMed [journal] PMID: 21423218,
PMCID: PMC3406293

Shmookler Reis RJ, Xu L, Lee H, Chae M, Thaden JJ, Bharill P, Tazearslan C,
Siegel E, Alla R, Zimniak P, Ayyadevara S.  Modulation of lipid biosynthesis
contributes to stress resistance and longevity of C. elegans mutants. Aging.
2011; 3(2):125-47. PubMed [journal] PMID: 21386131, PMCID: PMC3082008

Johnson CH, Ayyadevara S, McEwen JE, Shmookler Reis RJ. Histoplasma capsulatum
and Caenorhabditis elegans: a simple nematode model for an innate immune response
to fungal infection. Medical mycology. 2009; 47(8):808-13. PubMed [journal] PMID:
20028234

Ayyadevara S, Tazearslan C, Bharill P, Alla R, Siegel E, Shmookler Reis RJ.
Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional
stress resistance and lifespan. Aging cell. 2009; 8(6):706-25. NIHMSID:
NIHMS214182 PubMed [journal] PMID: 19764929, PMCID: PMC2917200

Shmookler Reis RJ, Bharill P, Tazearslan C, Ayyadevara S. Extreme-longevity
mutations orchestrate silencing of multiple signaling pathways. Biochimica et
biophysica acta. 2009; 1790(10):1075-83. NIHMSID: NIHMS119746 PubMed [journal]
PMID: 19465083, PMCID: PMC2885961

Tazearslan C, Ayyadevara S, Bharill P, Shmookler Reis RJ. Positive feedback
between transcriptional and kinase suppression in nematodes with extraordinary
longevity and stress resistance. PLoS genetics. 2009; 5(4):e1000452. PubMed
[journal] PMID: 19360094, PMCID: PMC2661368

Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Dysfunctional
homologous recombination mediates genomic instability and progression in myeloma.
Blood. 2009; 113(10):2290-7. PubMed [journal] PMID: 19050310, PMCID: PMC2652372

Chae M, Shmookler Reis RJ, Thaden JJ. An iterative block-shifting approach to
retention time alignment that preserves the shape and area of gas
chromatography-mass spectrometry peaks. BMC bioinformatics. 2008; 9 Suppl 9:S15.
PubMed [journal] PMID: 18793460, PMCID: PMC2537566

Ayyadevara S, Alla R, Thaden JJ, Shmookler Reis RJ. Remarkable longevity and
stress resistance of nematode PI3K-null mutants. Aging cell. 2008; 7(1):13-22.
PubMed [journal] PMID: 17996009

Lee T, Desai VG, Velasco C, Reis RJ, Delongchamp RR. Testing for treatment
effects on gene ontology. BMC bioinformatics. 2008; 9 Suppl 9:S20. PubMed
[journal] PMID: 18793466, PMCID: PMC2537571

Szumska D, Benes H, Kang P, Weinstein RS, Jilka RL, Manolagas SC, Shmookler Reis
RJ. A novel locus on the X chromosome regulates post-maturity bone density
changes in mice. Bone. 2007; 40(3):758-66. NIHMSID: NIHMS18997 PubMed [journal]
PMID: 17185055, PMCID: PMC1861851

Ayyadevara S, Dandapat A, Singh SP, Siegel ER, Shmookler Reis RJ, Zimniak L,
Zimniak P. Life span and stress resistance of Caenorhabditis elegans are
differentially affected by glutathione transferases metabolizing
4-hydroxynon-2-enal. Mechanisms of ageing and development. 2007; 128(2):196-205.
NIHMSID: NIHMS17821 PubMed [journal] PMID: 17157356, PMCID: PMC1819584

Khaidakov M, Siegel ER, Shmookler Reis RJ. Direct repeats in mitochondrial DNA
and mammalian lifespan. Mechanisms of ageing and development. 2006;
127(10):808-12. PubMed [journal] PMID: 16956646

Shmookler Reis RJ, Kang P, Ayyadevara S. Quantitative trait loci define genes and
pathways underlying genetic variation in longevity. Experimental gerontology.
2006; 41(10):1046-54. PubMed [journal] PMID: 16919411

Ayyadevara S, Dandapat A, Singh SP, Benes H, Zimniak L, Shmookler Reis RJ,
Zimniak P. Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis
elegans is partially mediated by glutathione transferase CeGSTP2-2. Aging cell.
2005; 4(6):299-307. PubMed [journal] PMID: 16300482

Parsons CA, Mroczkowski HJ, McGuigan FE, Albagha OM, Manolagas S, Reid DM,
Ralston SH, Shmookler Reis RJ. Interspecies synteny mapping identifies a
quantitative trait locus for bone mineral density on human chromosome Xp22. Human
molecular genetics. 2005; 14(21):3141-8. PubMed [journal] PMID: 16183656

Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis
RJ, Liebau E, Zimniak P. Lifespan and stress resistance of Caenorhabditis elegans
are increased by expression of glutathione transferases capable of metabolizing
the lipid peroxidation product 4-hydroxynonenal. Aging cell. 2005; 4(5):257-71.
PubMed [journal] PMID: 16164425

Khaidakov M, Shmookler Reis RJ. Possibility of selection against mtDNA mutations
in tumors. Molecular cancer. 2005; 4:36. PubMed [journal] PMID: 16159390, PMCID:
PMC1232865

McEwen JE, Zimniak P, Mehta JL, Shmookler Reis RJ. Molecular pathology of aging
and its implications for senescent coronary atherosclerosis. Current opinion in
cardiology. 2005; 20(5):399-406. PubMed [journal] PMID: 16093759

Khaidakov M, Chavannes-Turesky N, Cooney CA, Dupont-Versteegden EE, Kennedy RH,
Siegel ER, Khaidakova G, Shmookler Reis RJ. Contribution of de novo point
mutations to the overall mutational burden in mitochondrial DNA of adult rats.
Experimental gerontology. 2005; 40(5):396-402. PubMed [journal] PMID: 15919591

Shammas MA, Liu X, Gavory G, Raney KD, Balasubramanian S, Shmookler Reis RJ.
Targeting the single-strand G-rich overhang of telomeres with PNA inhibits cell
growth and induces apoptosis of human immortal cells. Experimental cell research.
2004; 295(1):204-14. PubMed [journal] PMID: 15051503

Shammas MA, Shmookler Reis RJ, Li C, Koley H, Hurley LH, Anderson KC, Munshi NC.
Telomerase inhibition and cell growth arrest after telomestatin treatment in
multiple myeloma. Clinical cancer research. 2004; 10(2):770-6. PubMed [journal] PMID:
14760100

Shammas MA, Shmookler Reis RJ, Akiyama M, Koley H, Chauhan D, Hideshima T, Goyal
RK, Hurley LH, Anderson KC, Munshi NC. Telomerase inhibition and cell growth
arrest by G-quadruplex interactive agent in multiple myeloma. Molecular cancer
therapeutics. 2003; 2(9):825-33. PubMed [journal] PMID: 14555701

Shmookler Reis RJ, Ebert RH 2nd. Animal models for discovery and assessment of
genetic determinants of osteoporosis. Osteoporosis international. 2003; 14 Suppl
5:S100-6. PubMed [journal] PMID: 14504713

Ayyadevara S, Ayyadevara R, Vertino A, Galecki A, Thaden JJ, Shmookler Reis RJ.
Genetic loci modulating fitness and life span in Caenorhabditis elegans:
categorical trait interval mapping in CL2a x Bergerac-BO recombinant-inbred
worms. Genetics. 2003; 163(2):557-70. PubMed [journal] PMID: 12618395, PMCID:
PMC1462449

Shmookler Reis RJ. From QTL mapping to genes: the long and winding road. J
bone mineral research. 2003; 18(2):186-9. PubMed [journal] PMID: 12568394

Batchu RB, Shammas MA, Wang JY, Shmookler Reis RJ, Munshi NC. Interaction of
adeno-associated virus Rep78 with SV40 T antigen: implications in Rep protein
expression leading to the inhibition of SV40-mediated cell proliferation.
Intervirology. 2002; 45(2):115-8. PubMed [journal] PMID: 12145545

Batchu RB, Shammas MA, Wang JY, Shmookler Reis RJ, Munshi NC. Expression of AAV
Rep proteins in SV40-transformed and untransformed cells: reciprocal interaction
with host DNA synthesis. Intervirology. 2001; 44(5):298-305. PubMed [journal]
PMID: 11684891

Miller RA, Galecki A, Shmookler-Reis RJ. Interpretation, design, and analysis of
gene array expression experiments. J gerontology A, Biological sciences & medical
sciences. 2001; 56(2):B52-7. PubMed [journal] PMID: 11213267

Ayyadevara S, Ayyadevara R, Hou S, Thaden JJ, Shmookler Reis RJ. Genetic mapping
of quantitative trait loci governing longevity of Caenorhabditis elegans in
recombinant-inbred progeny of a Bergerac-BO x RC301 interstrain cross. Genetics.
2001; 157(2):655-66. PubMed [journal] PMID: 11156986, PMCID: PMC1461506

Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Anchor polymerase chain reaction
display: a high-throughput method to resolve, score, and isolate dimorphic
genetic markers based on interspersed repetitive DNA elements. Analytical
biochemistry. 2000; 284(1):19-28. PubMed [journal] PMID: 10933851

Ayyadevara S, Thaden JJ, Shmookler Reis RJ. Discrimination of primer
3'-nucleotide mismatch by taq DNA polymerase during polymerase chain reaction.
Analytical biochemistry. 2000; 284(1):11-8. PubMed [journal] PMID: 10933850

Cherkasova V, Ayyadevara S, Egilmez N, Shmookler Reis R. Diverse Caenorhabditis
elegans genes that are upregulated in dauer larvae also show elevated transcript
levels in long-lived, aged, or starved adults. Journal of molecular biology.
2000; 300(3):433-48. PubMed [journal] PMID: 10884342

Benes H, Weinstein RS, Zheng W, Thaden JJ, Jilka RL, Manolagas SC, Shmookler Reis
RJ. Chromosomal mapping of osteopenia-associated quantitative trait loci using
closely related mouse strains. Journal of bone and mineral research. 2000;
15(4):626-33. PubMed [journal] PMID: 10780854

Thaden JJ, Shmookler Reis RJ. Ammonia, respiration, and longevity in nematodes:
insights on metabolic regulation of life span from temporal rescaling. Journal of
the American Aging Association. 2000; 23(2):75-84. PubMed [journal] PMID:
23604841, PMCID: PMC3455786

Shammas MA, Simmons CG, Corey DR, Shmookler Reis RJ. Telomerase inhibition by
peptide nucleic acids reverses 'immortality' of transformed human cells.
Oncogene. 1999; 18(46):6191-200. PubMed [journal] PMID: 10597217

Shammas MA, Shmookler Reis RJ. Recombination and its roles in DNA repair,
cellular immortalization and cancer. Age. 1999; 22(2):71-88. PubMed [journal]
PMID: 23604399, PMCID: PMC3455241

Li J, Ayyadevera R, Shmookler Reis RJ. Carcinogens stimulate intrachromosomal
homologous recombination at an endogenous locus in human diploid fibroblasts.
Mutation research. 1997; 385(3):173-93. PubMed [journal] PMID: 9506887

Xia SJ, Shammas MA, Shmookler Reis RJ. Elevated recombination in immortal human
cells is mediated by HsRAD51 recombinase. Molecular and cellular biology. 1997;
17(12):7151-8. PubMed [journal] PMID: 9372947, PMCID: PMC232572

Lecka-Czernik B, Moerman EJ, Shmookler Reis RJ, Lipschitz DA. Cellular and
molecular biomarkers indicate precocious in vitro senescence in fibroblasts from
SAMP6 mice. Evidence supporting a murine model of premature senescence and
osteopenia. J gerontology A, Biological sciences & medical sciences. 1997;
52(6):B331-6. PubMed [journal] PMID: 9402934

Cheng RZ, Shammas MA, Li J, Shmookler Reis RJ. Expression of SV40 large T antigen
stimulates reversion of a chromosomal gene duplication in human cells.
Experimental cell research. 1997; 234(2):300-12. PubMed [journal] PMID: 9260898

Shammas MA, Xia SJ, Shmookler Reis RJ. Induction of duplication reversion in
human fibroblasts, by wild-type and mutated SV40 T antigen, covaries with the
ability to induce host DNA synthesis. Genetics. 1997; 146(4):1417-28. PubMed
[journal] PMID: 9258684, PMCID: PMC1208085

van Swinderen B, Shook DR, Ebert RH, Cherkasova VA, Johnson TE, Shmookler Reis
RJ, Crowder CM. Quantitative trait loci controlling halothane sensitivity in
Caenorhabditis elegans. Proceedings of the National Academy of Sciences U.S.A. 1997;
94(15):8232-7. PubMed [journal] PMID: 9223344, PMCID: PMC21586

Nikitin AG, Shmookler Reis RJ. Role of transposable elements in age-related
genomic instability. Genetical research. 1997; 69(3):183-95. PubMed [journal]
PMID: 9290321

Xia SJ, Shammas MA, Shmookler Reis RJ. Reduced telomere length in
ataxia-telangiectasia fibroblasts. Mutation research. 1996; 364(1):1-11. PubMed
[journal] PMID: 8814333

Ebert RH 2nd, Shammas MA, Sohal BH, Sohal RS, Egilmez NK, Ruggles S, Shmookler
Reis RJ. Defining genes that govern longevity in Caenorhabditis elegans.
Developmental genetics. 1996; 18(2):131-43. PubMed [journal] PMID: 8934875

Shmookler Reis RJ, Ebert RH 2nd. Genetics of aging: current animal models.
Experimental gerontology. 1996; 31(1-2):69-81. PubMed [journal] PMID: 8706806

Egilmez NK, Ebert RH 2nd, Shmookler Reis RJ. Strain evolution in Caenorhabditis
elegans: transposable elements as markers of interstrain evolutionary history.
Journal of molecular evolution. 1995; 40(4):372-81. PubMed [journal] PMID:
7769614

Egilmez NK, Shmookler Reis RJ. Age-dependent somatic excision of transposable
element Tc1 in Caenorhabditis elegans. Mutation research. 1994; 316(1):17-24.
PubMed [journal] PMID: 7507565

Ebert RH 2nd, Cherkasova VA, Dennis RA, Wu JH, Ruggles S, Perrin TE, Shmookler
Reis RJ. Longevity-determining genes in Caenorhabditis elegans: chromosomal
mapping of multiple noninteractive loci. Genetics. 1993; 135(4):1003-10. PubMed
[journal] PMID: 8307318, PMCID: PMC1205733

Murano S, Thweatt R, Shmookler Reis RJ, Jones RA, Moerman EJ, Goldstein S.
Diverse gene sequences are overexpressed in werner syndrome fibroblasts
undergoing premature replicative senescence. Molecular and cellular biology.
1991; 11(8):3905-14. PubMed [journal] PMID: 1712899, PMCID: PMC361182

Henle KJ, Shmookler Reis RJ, Lumpkin CK. Modulation of cellular glycosidase
activity by hyperthermia. International journal of hyperthermia 1991; 7(3):531-7.
PubMed [journal] PMID: 1833475

Thweatt R, Goldstein S, Shmookler Reis RJ. A universal primer mixture for
sequence determination at the 3' ends of cDNAs. Analytical biochemistry. 1990;
190(2):314-6. PubMed [journal] PMID: 2291476

Cheng RZ, Murano S, Kurz B, Shmookler Reis RJ. Homologous recombination is
elevated in some Werner-like syndromes but not during normal in vitro or in vivo
senescence of mammalian cells. Mutation research. 1990; 237(5-6):259-69. PubMed
[journal] PMID: 2079965

Goldstein S, Jones RA, Hardin JW, Braunstein GD, Shmookler Reis RJ. Expression of
alpha- and beta-human chorionic gonadotropin subunits in cultured human cells. In
vitro cellular & dev biology 1990; 26(9):857-64. PubMed [journal] PMID: 1699921

Srivastava A, Shmookler Reis RJ, Goldstein S. Absence of reverse transcriptase
activity in human diploid fibroblasts. Mechanisms of ageing and development.
1990; 51(2):133-8. PubMed [journal] PMID: 1689785

Goldstein S, Murano S, Shmookler Reis RJ. Werner syndrome: a molecular genetic
hypothesis. Journal of gerontology. 1990; 45(1):B3-8. PubMed [journal] PMID:
2404059

Shmookler Reis RJ, Finn GK, Smith K, Goldstein S. Clonal variation in gene
methylation: c-H-ras and alpha-hCG regions vary independently in human fibroblast
lineages. Mutation research. 1990; 237(1):45-57. PubMed [journal] PMID: 2157149

Houde M, Shmookler Reis RJ, Goldstein S. Proportions of H1 histone subspecies in
human fibroblasts shift during density-dependent growth arrest independent of
replicative senescence. Experimental cell research. 1989; 184(1):256-61. PubMed
[journal] PMID: 2792226

Finn GK, Kurz BW, Cheng RZ, Shmookler Reis RJ. Homologous plasmid recombination
is elevated in immortally transformed cells. Molecular and cellular biology.
1989; 9(9):4009-17. PubMed [journal] PMID: 2550810, PMCID: PMC362463

Shmookler Reis RJ. Model systems for aging research: syncretic concepts and
diversity of mechanisms. Genome. 1989; 31(1):406-12. PubMed [journal] PMID:
2687106

Goldstein S, Murano S, Benes H, Moerman EJ, Jones RA, Thweatt R, Shmookler Reis
RJ, Howard BH. Studies on the molecular-genetic basis of replicative senescence
in Werner syndrome and normal fibroblasts. Experimental gerontology. 1989;
24(5-6):461-8. PubMed [journal] PMID: 2632280

Shmookler Reis RJ. Strategies and criteria for the development of molecular
biomarkers of senescence. Experimental gerontology. 1988; 23(4-5):271-80. PubMed
[journal] PMID: 3058490

Shmookler Reis RJ, Srivastava A, Beranek DT, Goldstein S. Human alphoid family of
tandemly repeated DNA. Sequence of cloned tetrameric fragments and analysis of
familial divergence. Journal of molecular biology. 1985; 186(1):31-41. PubMed
[journal] PMID: 3001316

Goldstein S, Shmookler Reis RJ. Methylation patterns in the gene for the alpha
subunit of chorionic gonadotropin are inherited with variable fidelity in clonal
lineages of human fibroblasts. Nucleic acids research. 1985; 13(19):7055-65.
PubMed [journal] PMID: 4059053, PMCID: PMC322022

Riabowol K, Shmookler Reis RJ, Goldstein S. Interspersed repetitive and tandemly
repetitive sequences are differentially represented in extrachromosomal
covalently closed circular DNA of human diploid fibroblasts. Nucleic acids
research. 1985; 13(15):5563-84. PubMed [journal] PMID: 2994003, PMCID: PMC321890

Srivastava A, Norris JS, Shmookler Reis RJ, Goldstein S. c-Ha-ras-1
proto-oncogene amplification and overexpression during the limited replicative
life span of normal human fibroblasts. The Journal of biological chemistry. 1985;
260(10):6404-9. PubMed [journal] PMID: 3997829

Goldstein S, Srivastava A, Riabowol KT, Shmookler Reis RJ. Changes in genetic
organization and expression in aging cells. Basic life sciences. 1985; 35:255-67.
PubMed [journal] PMID: 4062813

Lumpkin CK Jr, McGill JR, Riabowol KT, Moerman EJ, Shmookler Reis RJ, Goldstein
S. Extrachromosomal circular DNA and aging cells. Advances in experimental
medicine and biology. 1985; 190:479-93. PubMed [journal] PMID: 3002151

Goldstein S, Srivastava A, Riabowol K, Shmookler Reis RJ. Alterations in genome
structure and expression in aging human fibroblasts. Progress in clinical and
biological research. 1985; 195:1-14. PubMed [journal] PMID: 2997801

Goldstein S, Shmookler Reis RJ. Genetic modifications during cellular aging.
Molecular and cellular biochemistry. 1984; 64(1):15-30. PubMed [journal] PMID:
6387441

Goldstein S, Shmookler Reis RJ. Genomic plasticity in aging human cells. Annual
reviews of gerontology & geriatrics. 1984; 4:33-57. PubMed [journal] PMID: 6443554

Shmookler Reis RJ, Goldstein S. Mitochondrial DNA in mortal and immortal human
cells. Genome number, integrity, and methylation. The Journal of biological
chemistry. 1983; 258(15):9078-85. PubMed [journal] PMID: 6307991

Shmookler Reis RJ, Lumpkin CK Jr, McGill JR, Riabowol KT, Goldstein S.
Extrachromosomal circular copies of an 'inter-Alu' unstable sequence in human DNA
are amplified during in vitro and in vivo ageing. Nature. 1983; 301(5899):394-8.
PubMed [journal] PMID: 6823315

Shmookler Reis RJ, Lumpkin CK Jr, McGill JR, Riabowol KT, Goldstein S. Genome
alteration during in vitro and in vivo aging: amplification of extrachromosomal
circular DNA molecules containing a chromosomal sequence of variable repeat
frequency. Cold Spring Harbor symposia on quantitative biology. 1983; 47 Pt
2:1135-9. PubMed [journal] PMID: 6574863

Shmookler Reis RJ, Goldstein S. Interclonal variation in methylation patterns for
expressed and non-expressed genes. Nucleic acids research. 1982; 10(14):4293-304.
PubMed [journal] PMID: 6896910, PMCID: PMC320800

97. hmookler Reis RJ, Goldstein S. Variability of DNA methylation patterns during
serial passage of human diploid fibroblasts. Proceedings of the National Academy
of Sciences U.S.A. 1982; 79(13):3949-53. PubMed
[journal] PMID: 6287455, PMCID: PMC346553

Harley CB, Shmookler Reis RJ, Goldstein S. Loss of repetitious DNA in
proliferating somatic cells may be due to unequal recombination. Journal of
theoretical biology. 1982; 94(1):1-12. PubMed [journal] PMID: 7078201

Shmookler Reis RJ. Ribosomes from aging mice are not generally deficient in
cell-free protein synthesis. Mechanisms of ageing and development. 1981;
17(4):311-20. PubMed [journal] PMID: 7329100

Shmookler Reis R, Timmis JN, Ingle J. Divergence, differential methylation and
interspersion of melon satellite DNA sequences. The Biochemical journal. 1981;
195(3):723-34. PubMed [journal] PMID: 6172117, PMCID: PMC1162945

Shmookler Reis RJ, Goldstein S. Loss of reiterated DNA sequences during serial
passage of human diploid fibroblasts. Cell. 1980; 21(3):739-49. PubMed [journal]
PMID: 6254666

Shmookler Reis RJ, Goldstein S, Harley CB. Is cellular aging a stochastic
process? Mechanisms of ageing and development. 1980; 13(4):393-5. PubMed
[journal] PMID: 7442329

Shmookler Reis RJ. A sensitive microassay of nucleic acids. Analytical
biochemistry. 1978; 90(2):821-3. PubMed [journal] PMID: 727512

Shmookler Reis RJ, Biro PA. Sequence and evolution of mouse satellite DNA.
Journal of molecular biology. 1978; 121(3):357-74. PubMed [journal] PMID: 671543

Shmookler Reis RJ., Buss J, Green MH..Properties of the polyoma virus transcription
complex obtained from mouse nuclei.
Virology. 1974; 57:122-127.

Shmookler Reis RJ. Enzyme fidelity and metazoan aging.
Interdisciplinary topics in gerontology. 1976; 10:11-23.

Shmookler Reis RJ., Goldstein S.  Mécanismes moléculaires du vieillissement cellulaire
(Molecular mechanisms for cellular aging) 
Assoc. Canadienne Francaise pour l'Avancement des Sciences (ACFAS) Annales. 1981;
7:143-157.

The Future of Aging (book chapter)
Shmookler Reis RJ., McEwen JoanE.
Fahy GM., West MD., Coles L, Harris SB., editors. Dordrecht: Springer; 2010.
Chapter 20, Methuselah’s DNA: Defining genes that can extend longevity  pp. 623-640.

Oxidative Stress and Aging (book chapter)
Shmookler Reis RJ.
Cutler RG., Rodriguez H, editors. New Jersey: World Scientific; 2003. Chapter 67,
Toward a unified theory of aging — What mammals can learn from worms and other
ephemeral creatures  pp. 1263-1283.

The role of DNA damage and repair in cellular aging (book chapter)
Shmookler Reis RJ., Shammas MA..
Gilchrest BA., Bohr V, editors. Amsterdam: Elsevier; 2001. DNA instability,
telomeric recombination, and cell transformation.  pp. 135-151.