Mazur, Anna Ph.D    

Position title: Postdoctoral Fellow, Dept. of Geriatrics, University of Arkansas for Medical Sciences.
    
My primary research interests focus on discovering approaches that aid in innovative cryopreservation methods of whole organs. In my studies I use C. elegans nematodes as a model organism to delineate molecular pathways leading to increased survival after cryopreservation and to address toxicity of novel cryopreservatives.
Additionally, I have a great interest in mechanisms underlying aging in C. elegans. In these studies I focus on signaling pathways that regulate life extension in this organism to define specific molecular mediators (i.e. transcription factors) responsible for increased lifespan.
My current scientific interests stem from research training that I originally received in biochemistry where I worked on structure and function studies of human phase II metabolism enzymes UDP-glucuronosyltransferases and their substrate specificity [1-3]. Subsequently, I studied stromal interactions between cells in the tumor microenvironment, regulated by tumor-specific protease FAP [4-6]. These studies culminated in receiving my PhD degree and cemented my interest in unraveling the molecular mechanisms underlying chronic inflammatory conditions, life-altering disorders, and lifespan itself. My training in these fields result in broad experience with different animal models, cell culture, ex vivo studies, and biochemical and molecular biology methods.

1.    Miller GP, Lichti CF, Zielinska AK, Mazur A, Bratton SM, Gallus-Zawada A, Finel M, Moran JH, Radominska-Pandya A. Identification of Hydroxywarfarin Binding Site in Human UDP-Glucuronosyltransferase 1A10: Phenylalanine90 Is Crucial for the Glucuronidation of 6- and 7-Hydroxywarfarin but Not 8-Hydroxywarfarin. Drug Metab Dispos, 2008 Nov; 36(11): 2211-8.

2.    Mazur A, Litchi CF, Prather PL, Zielinska AK, Bratton SM, Gallus-Zawada A, Finel M, Miller GP, Radominska-Pandya A, Moran JH. Characterization of human hepatic and extrahepatic UDP-Glucuronosyltransferase enzymes involved in metabolism of classic cannabinoids. Drug Metab Dispos, 2009 Jul; 37(7): 1496-504.

3.    Miller GP, Jones DR, Sullivan SH, Mazur A, Owen SN, Mitchell NC, Radominska-Pandya A, Moran JH. Assessing cytochrome P450 and UDP-glucuronosyltransferase contributions to warfarin metabolism in humans. Chem Res Toxicol. 2009 Jul; 22(7): 1239-45.

4.    Huang Y, Simms AE, Mazur A, Wang S, Leon NR, Jones B, Aziz N, Kelly T. Fibroblast Activation Protein-α promotes tumor growth and invasion of breast cancer cells through non-enzymatic functions. Clin Exp Metastasis, 2011 Aug; 28(6): 567-79.

5.    Kelly T, Huang Y, Simms AE, Mazur A. Fibroblast Activation Protein-α: a key regulator of the microenvironment in multiple pathologies. Int Rev Cell Mol Biol, 2012; 297: 83-116.

6. Mazur A, Vadali S, Kelly T, Post SR. Cleavage of Type I Collagen by Fibroblast Activation Protein-α Enhances Class A Scavenger Receptor Mediated Macrophage Adhesion. PLoS One, 2016 Mar;11(3): e0150287